Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies

Diabetes mellitus (DM) is a worldwide public health problem that affects millions of people from all age, gender, and racial and ethnic groups. DM is the leading cause of blindness and amputation and contributes substantially to kidney disease, cardiomyopathy, and cerebrovascular and peripheral artery diseases. Of importance, recent advances in biology and medicine have introduced new technologies to study the molecular pathology underlying DM-related complications, the development of novel strategies to treat these conditions, and the evaluation of outcomes.