Plasma fibrinogen determinations were performed before and after cryoprecipitate infusion in two hemophiliacs who received periodic infusions on prophylactic basis. The mean increases in plasma fibrinogen were 6.5 mg 100 ml per unit infused in one patient and 5.1 in the other. This corresponds to an administered dose of 205 mg/unit of cryoprecipitate. Cryoprecipitate offers the advantage of decreased hepatitis risk, but the disadvantage of wide variation in fibrinogen content.
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Soloway et al. (1970) studied this question.
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