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A regioselective macrolactonization and a one-pot synthesis are the key steps in the first total synthesis of tricolorin A (1), the principal component of a plant used in traditional Mexican agriculture for weed control. The synthesis of this macrolactone tetrasaccharide, which starts from D-(+)-mannitol, contains 45 steps with a longest linear sequence of 20 steps (overall yield 0.65%).
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Lu et al. (1997) studied this question.
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