Key result
The Cepheid GeneXpert Xpert Flu assay demonstrated an overall sensitivity of 95.3% and specificity of 99.2% compared with the Prodesse ProFlu+ assay.
Why the study?
Does the Xpert Flu assay have comparable diagnostic performance to the Prodesse ProFlu+ assay in high-risk emergency department patients with acute respiratory illness?
Observational (n=281)
Does the Xpert Flu assay have comparable diagnostic performance to the Prodesse ProFlu+ assay in high-risk emergency department patients with acute respiratory illness?
The Xpert Flu Rapid PCR Assay demonstrates high sensitivity and specificity for detecting influenza in high-risk emergency department patients.
Supports rapid influenza testing in antiviral-eligible ED adults; leaves open impact on prescribing decisions and outcomes.
We prospectively evaluated the performance of Cepheid's GeneXpert Xpert Flu assay in a target population of 281 adults presenting to the emergency department with an acute respiratory illness who met Centers for Disease Control and Prevention (CDC) criteria for recommended antiviral treatment. Compared with the Prodesse ProFlu+ assay, Xpert Flu had an overall sensitivity of 95.3% and specificity of 99.2%.
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Dugas et al. (2014) conducted an observational in Acute respiratory illness (n=281). Cepheid's GeneXpert Xpert Flu assay vs. Prodesse ProFlu+ assay was evaluated on Overall sensitivity and specificity (sensitivity 95.3%, specificity 99.2%). The Cepheid GeneXpert Xpert Flu assay demonstrated an overall sensitivity of 95.3% and specificity of 99.2% compared with the Prodesse ProFlu+ assay.
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