Key result
Calcium regulates cardiac contraction by driving pacemaker activity, excitation-contraction coupling, and transcriptional events that remodel the signaling system in health and disease.
Design
Review
Calcium signaling informs arrhythmia and HF management; extends mechanistic understanding of transcriptional remodeling for targeted research.
Calcium regulates three different aspects of cardiac contraction. It drives pacemaker activity, excitation-contraction coupling and the transcriptional events that remodel the Ca(2+) signalling system in both health and disease.
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Michael J. Berridge (2003) studied this question. Calcium regulates cardiac contraction by driving pacemaker activity, excitation-contraction coupling, and transcriptional events that remodel the signaling system in health and disease.
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