Metabolic Adaptations to a “Stuff and Starve” Feeding Program. Ii. Obesity and the Persistence of Adaptive Changes in Adipose Tissue and Liver Occurring in Rats Limited to a Short Daily Feeding Period*

Many obese people who want to lose weight seem unable to follow diets which will allow them to achieve and maintain ideal weight (1-3). This failure to follow diets has been ascribed to a lack of interest or to psychological factors, since no clear-cut abnormality in so-called simple or exogenous obesity other than excessive food in- take has been delineated (4).