Key result
Current literature on HDL genetics identifies 11 key genes and 6 newly proposed genes involved in HDL metabolism, providing insight into pathways and novel pharmacological targets.
This review summarizes current knowledge on HDL genetics, highlighting key genes involved in HDL metabolism and potential novel pharmacological targets for reducing atherosclerosis.
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Does not yet alter HDL management; extends genetic mapping but leaves open therapeutic validation in trials.
PURPOSE OF REVIEW: To review studies on hereditary disorders of high-density lipoprotein (HDL) metabolism and studies on HDL genetics in mice, which have both provided valuable insight into the pathways of this intriguing lipoprotein and moreover revealed targets to raise HDLc to reduce atherosclerosis. RECENT FINDINGS: To date, as many as 11 genes are considered key players in the synthesis, maturation, conversion and/or catabolism of HDL. Five of these genes have been identified in humans, APOA1, LCAT, ABCA1, LIPC, and CETP, whereas the other six genes have been identified in mice, SCARB1, ABCG1, ATPB5, PLTP, LIPG and APOM. Genetic association studies are as yet the best line of evidence of the roles of the 'murine genes' in human HDL pathways. In addition to recent genetic association studies, a third section describes exciting news on six newly proposed HDL genes VNN1, GALNT2, MMAB/MVK, CTalpha, BMP-1 and SIRT1. SUMMARY: This review provides a summary of the current literature on the genetics of HDL. New information from this research area may assist us in obtaining a better understanding of HDL biology and identifying novel pharmacological targets.
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Holleboom et al. (2008) conducted a review in Hereditary disorders of high-density lipoprotein (HDL) metabolism. HDL genetics was evaluated. Current literature on HDL genetics identifies 11 key genes and 6 newly proposed genes involved in HDL metabolism, providing insight into pathways and novel pharmacological targets.
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