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May 15, 1998Blood

Activation of Stat-3 Is Involved in the Induction of Apoptosis After Ligation of Major Histocompatibility Complex Class I Molecules on Human Jurkat T Cells

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Authors

SSSøren SkovUniversity of CopenhagenMNMette NielsenUniversity of CopenhagenSBSøren BregenholtRedx Pharma (United Kingdom)

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Skov et al. (1998) studied this question.

synapsesocial.com/papers/6a9bc511b8e9c4d36e6c7e5chttps://doi.org/10.1182/blood.v91.10.3566
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of human T cell clones and Jurkat cells by cross-linking class I MHC molecules.1989 · 67 citations
  2. 2Features of apoptotic cells measured by flow cytometry1992 · 1,913 citations
  3. 3MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis1997 · 77 citations
  4. 4IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 α and STAT3 complexes in human T cells and monocytes1995 · 428 citations
  5. 5MHC class I signaling in T cells leads to tyrosine kinase activity and PLC-gamma 1 phosphorylation.1995 · 46 citations