Dilantin®, Agranulocytosis, and Phagocytic Marrow Histocytes

Letters1 June 1976Dilantin®, Agranulocytosis, and Phagocytic Marrow HistocytesMIN-FU TSAN, M.D., PH.D., DAVID J. MEHLMAN, M.D., ROBERT S. GREEN, M.D., WILLIAM R. BELL, M.D., F.A.C.P.MIN-FU TSAN, M.D., PH.D.Search for more papers by this author, DAVID J. MEHLMAN, M.D.Search for more papers by this author, ROBERT S. GREEN, M.D.Search for more papers by this author, WILLIAM R. BELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-6-710 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAgranulocytosis associated with Dilantin®* (diphenylhydantoin) therapy has been reported in five cases (1-5) and only two had bone-marrow aspiration during the acute stage (3-4). We report the occurrence of agranulocytosis with marked phagocytosis of myeloid precursors by marrow histiocytes in a patient taking Dilantin.A 15-year-old black girl was admitted to the Johns Hopkins Hospital after having fever and chills for 3 days. She had complained of intermittent headache, episodic abdominal pain, and momentary loss of consciousness in the 5 months before admission, but no abnormality was found on examination and electroencephalography. Because of increasingly frequent attacks, treatment with Dilantin...References1. DICKERSON W: The present status of Dilantin therapy. Am J Psychiatry 98:515-523, 1942 CrossrefGoogle Scholar2. ARINGROSENBAUM CM: Ingestion of large doses of Dilantin Sodium. Arch Neurol Psychiatry 45:265-270, 1941 CrossrefGoogle Scholar3. SCHOEMPERLEN C: Agranulocytosis after diphenylhydantoin and chlorothiazide therapy. Arch Intern Med 108:184-188, 1961 Google Scholar4. SLAVINBROWN RG: Agranulocytosis after diphenylhydantoin and chlorothiazide therapy. Arch Intern Med 108:184-188, 1961 CrossrefGoogle Scholar5. TURNER P: Granulocytopenia after treatment with pheytoin sodium. Br Med J 1:1790, 1960 CrossrefMedlineGoogle Scholar6. MCINTYRELALELIHODKINSON PYB: Evidence for anti-leukocyte antibodies as a mechanism for drug-induced agranulocytosis. Trans Assoc Am Physicians 84:217-228, 1971 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Medicine and Pediatrics The Johns Hopkins University and Hospital Baltimore, MD 21205*Parke, Davis & Co., Detroit, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndromeHemophagocytic lymphohistiocytosisHemophagocytic syndrome associated with hematological neoplasiasLiver changes in reactive haemophagocytic syndromePeripheral T-cell lymphoma presenting as hemophagocytic syndromeHistiocytic cytophagic panniculitisReactive histiocytic hyperplasia with hemophagocytosis in hematopoietic organs: A reevaluation of the benign hemophagocytic proliferationsHISTIOCYTOSIS IN BABY WITH DELAYED CORD SEPARATIONReactive hemophagocytic syndrome: A study of 7 fatal casesTuberculosis-associated hemophagocytic syndrome:A systemic processAntiepileptic drug toxicity: Definition and mechanism of actionBacteria-associated hemophagocytic syndromeAgranulocytosis, Procainamide, and PhenytoinSTEPHEN FLEET, M.D.Phenytoin-induced agranulocytosis after treatment for a gunshot wound to the faceReview of Cimetidine Drug InteractionsAntigranulocyte antibodies and deranged immune function associated with phenytoin-induced serum sicknessSevere Granulocytopenia with Cimetidine and PhenytoinELIZABETH SAZIE, M.D., JEFFRY P. JAFFE, M.D.Cimetidine and AgranulocytosisFIRAS H. AL-KAWAS, M.D., BRUCE A. LENES, M.D., RONALD A. SACHER, M.D.Agranulocytosis associated with an infected mandibular fractureAnticonvulsants 1 June 1976Volume 84, Issue 6Page: 710-711KeywordsAbdominal painBone marrowElectroencephalographyFeversHeadachesHistiocytesLoss of consciousnessPhagocytosis Issue Published: 1 June 1976 PDF downloadLoading ...