Hemophagocytic lymphohistiocytosis (hlh) associated with t-cell lymphomas: broadening our differential for fever of unknown origin

CONTEXT: Hemophagocytic lymphohistiocytosis (HLH), due to the excessive activity of histiocytes and lymphocytes, is a rare but aggressive disease that typically occurs in infancy but can be seen in all ages. If left untreated, patients with HLH may live for only a few months and die from multi-organ failure. CASE REPORT: We present two cases of HLH diagnosis. Fever, spleen, and hepatic abnormalities were noted in both cases. CONCLUSION: Early diagnosis is the key and these two cases of similar etiology highlight how fever of unknown origin should force us to broaden our differential.