Key result
Higher stages of acute kidney injury according to RIFLE, AKIN, and KDIGO classifications were statistically associated with increased mortality in diabetic patients undergoing pump-assisted coronary artery bypass surgery.
Why the study?
Different criteria exist to diagnose acute kidney injury, and the study aimed to evaluate the role of AKIN, KDIGO, SOFA, and RIFLE scores in diabetic patients undergoing pump-assisted coronary artery bypass graft surgery.
Do AKIN, KDIGO, SOFA, and RIFLE criteria predict mortality in diabetic patients undergoing pump-assisted coronary artery bypass surgery?
Cross-Sectional (n=310)
No
Do AKIN, KDIGO, SOFA, and RIFLE criteria predict mortality in diabetic patients undergoing pump-assisted coronary artery bypass surgery?
Higher stages of acute kidney injury according to RIFLE, AKIN, and KDIGO criteria are significantly associated with increased mortality in diabetic patients undergoing pump-assisted CABG.
AKI staging may aid mortality risk stratification in diabetic on-pump CABG; hypothesis-generating and requires prospective validation before clinical adoption.
Background Different definitions and criteria have emerged today to diagnose acute kidney injury. For this purpose, AKIN, RIFLE, SOFA and KDIGO classifications have been developed. Our aim in this study is to determine the role of AKIN, KDIGO, SOFA and RIFLE scores diabetic patients who underwent Pump-Assisted Coronary Artery Bypass Graft operation. Materials and Methods: Between January 2019 -December 2022, 310 diabetic patients who underwent Pump-Assisted Coronary Artery Bypass operation were included in this study. Our study is a cross-sectional retrospective study. In the cardiovascular surgery intensive care unit follow-up of the patients, perioperative data, intensive care follow-up charts, need for continuous renal replacement therapy, use of diuretics, use of inotropic agents, mechanical ventilator therapy, SOFA score, use of nephrotoxic drugs, and urine output were recorded. The RIFLE, KDIGO and AKIN scores of the patients were calculated daily and the highest value during the hospitalization was recorded. In addition to the length of stay in the intensive care unit, death and discharge status of the patients were also evaluated via The independent samples t-test (the distributions normal) was used to compare parametric data, whereas the Mann-Whitney U test was used to compare non-parametric data. Results: The mean age of 310 patients included in our study was 57.4±10.5 years. 132 (42.6%) of our patients were female and 178 (57.4%) were male. Death was observed in 7.8% of the patients included in the study. Not all of the deaths were due to renal failure, but these patients were seen to be in any stage of AKI according to the KDIGO, AKIN and RIFLE classification. According to the RIFLE, AKIN and KDIGO classifications, it was found that the mortality rate increased statistically as the Acute kidney injury stage increased. Conclusion: As the staging level in RIFLE, AKIN and KDIGO scores increases, the risk of renal failure increases. Checking these scores in patients scheduled for coronary artery bypass may reduce mortality.
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A 2025 study conducted a cross-sectional in Diabetic patients undergoing Pump-Assisted Coronary Artery Bypass Graft surgery (n=310). Acute kidney injury (AKI) stage (AKIN, KDIGO, RIFLE, SOFA criteria) vs. No acute kidney injury (Stage 0) was evaluated on Mortality (p=<0.05). Higher stages of acute kidney injury according to RIFLE, AKIN, and KDIGO classifications were statistically associated with increased mortality in diabetic patients undergoing pump-assisted coronary artery bypass surgery.
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