Uncovering strategies to rescue muscle mass in ageing

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Key Points

To examine cellular mechanisms driving age-related muscle wasting and evaluate therapeutic interventions designed to preserve skeletal muscle mass.
Synthesizes biological and clinical evidence regarding muscle atrophy, neuromuscular decline, and metabolic changes associated with senescence.
Assesses pharmacological, nutritional, and physical exercise interventions targeted at maintaining muscle protein homeostasis.
Age-related muscle loss stems from an imbalance between muscle protein synthesis and breakdown, compounded by reduced regenerative capacity.
Interventions that combine progressive resistance training with targeted nutritional supplementation effectively stimulate anabolic pathways and attenuate muscle decline.

Review uncovers strategies to rescue muscle mass in ageing adults, highlighting therapeutic targets to counteract progressive sarcopenia.

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Joelina Lienau (2026) studied this question.

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