Key result
Pulmonary vasodilators have failed to show clinical benefit and may increase mortality or heart failure exacerbations in patients with pulmonary hypertension secondary to left heart disease.
This review highlights the diagnostic challenges, hemodynamic assessment, and prognostic importance of identifying pulmonary hypertension out-of-proportion to left heart disease.
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May warrant avoiding pulmonary vasodilators in PH-LHD; confirms trial failures and leaves open refined phenotyping research.
Benza et al. (2006) conducted a review in Pulmonary hypertension secondary to left heart disease. Pulmonary vasodilators was evaluated. Pulmonary vasodilators have failed to show clinical benefit and may increase mortality or heart failure exacerbations in patients with pulmonary hypertension secondary to left heart disease.
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