Observational study reveals high hepatic steatosis risk linked to increased insulin needs in nonobese adults with type 1 diabetes, highlighting the need for liver screening.
Key Points
To evaluate the likelihood of hepatic steatosis using the hepatic steatosis index and assess its correlation with daily insulin requirements in nonobese adults with type 1 diabetes.
Assessed N=47 nonobese Chinese adults with type 1 diabetes (mean age 46.9 ± 14.1 years; mean BMI 22.6 ± 2.5 kg/m²).
Calculated hepatic steatosis index (HSI) scores, defining high likelihood of steatosis as HSI >36 and low likelihood as HSI <30, and compared insulin dose requirements between groups.
A high likelihood of steatosis (HSI >36) occurred in 27.7% of nonobese participants.
Individuals with an HSI >36 required significantly higher bolus and total daily insulin doses compared to those with an HSI <30, despite maintaining comparable glycemic profiles.