What does this research mean for the field?

Novel imidazolinone-benzenesulfonamide derivatives demonstrate excellent antitubercular and good antibacterial activity, with chloro and methoxy substituents significantly enhancing their antitubercular efficacy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To design, synthesize, and structurally characterize a novel series of imidazolinone–benzenesulfonamide hybrid derivatives and determine their in vitro antibacterial and antitubercular properties.

September 5, 2026Journal of Sulfur Chemistry

Design, synthesis, antibacterial and antitubercular evaluation of novel imidazolinone–benzenesulfonamide derivatives

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Authors

AGAbdallah Othman GhnaimLeo Pharma (Australia)MAMohammad Al-Raosh AAAya AldalatiLeo Pharma (Australia)

Discussion

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Overview

Preclinical in vitro study demonstrates potent antitubercular and antibacterial activity of novel imidazolinone–benzenesulfonamide derivatives, suggesting potential for new antimicrobial drug...

Key Points

To design, synthesize, and structurally characterize a novel series of imidazolinone–benzenesulfonamide hybrid derivatives and determine their in vitro antibacterial and antitubercular properties.
Synthesized derivatives via a multistep pathway coupling an imidazolinone core with aromatic amine sulfonamides, verified by IR, 1H NMR, 13C NMR, and mass spectrometry.
Tested antibacterial activity against three Gram-positive and four Gram-negative bacterial strains using the disc diffusion method with gentamicin as the reference standard.
Measured antitubercular efficacy against Mycobacterium tuberculosis H37Rv using the microplate Alamar blue assay with pyrazinamide as the positive control.
The synthesized derivatives exhibited effective antibacterial activity across all seven tested Gram-positive and Gram-negative bacterial strains.
Compounds displayed strong antitubercular activity against M. tuberculosis H37Rv, with analogs bearing chloro and methoxy substituents demonstrating significantly enhanced potency.

Cite This Study

Ghnaim et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd48c6b95aff0620ec497 https://doi.org/10.1080/17415993.2026.2726821

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September 5, 2026Journal of Sulfur Chemistry

Design, synthesis, antibacterial and antitubercular evaluation of novel imidazolinone–benzenesulfonamide derivatives

View Full Paper

Ask AI

Bookmark

Authors

AGAbdallah Othman GhnaimLeo Pharma (Australia)MAMohammad Al-Raosh AAAya AldalatiLeo Pharma (Australia)

Discussion

Member takes

Overview

Preclinical in vitro study demonstrates potent antitubercular and antibacterial activity of novel imidazolinone–benzenesulfonamide derivatives, suggesting potential for new antimicrobial drug...

Key Points

To design, synthesize, and structurally characterize a novel series of imidazolinone–benzenesulfonamide hybrid derivatives and determine their in vitro antibacterial and antitubercular properties.
Synthesized derivatives via a multistep pathway coupling an imidazolinone core with aromatic amine sulfonamides, verified by IR, 1H NMR, 13C NMR, and mass spectrometry.
Tested antibacterial activity against three Gram-positive and four Gram-negative bacterial strains using the disc diffusion method with gentamicin as the reference standard.
Measured antitubercular efficacy against Mycobacterium tuberculosis H37Rv using the microplate Alamar blue assay with pyrazinamide as the positive control.
The synthesized derivatives exhibited effective antibacterial activity across all seven tested Gram-positive and Gram-negative bacterial strains.
Compounds displayed strong antitubercular activity against M. tuberculosis H37Rv, with analogs bearing chloro and methoxy substituents demonstrating significantly enhanced potency.

Cite This Study

Ghnaim et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd48c6b95aff0620ec497 https://doi.org/10.1080/17415993.2026.2726821

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