Key result
Adverse intrauterine environmental exposures, such as maternal diabetes and hypoxia, induce epigenetic modifications that alter fetal cardiac programming and increase the risk of cardiovascular disease in adulthood.
Why the study?
Increasing focus has turned to the developmental origins of cardiovascular diseases, exploring how intrauterine environmental exposures affect fetal development and adult chronic disease risk.
Understanding epigenetic mechanisms in fetal cardiac programming provides insights into the developmental origins of cardiovascular disease and highlights potential future therapeutic targets.
Supports preconception optimization in diabetes; leaves open whether epigenetic therapies can reduce adult cardiovascular risk.
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Simmi Kharb (2021) conducted a review in Cardiovascular disease and fetal programming. Adverse intrauterine environment (e.g., maternal diabetes, hypoxia) was evaluated. Adverse intrauterine environmental exposures, such as maternal diabetes and hypoxia, induce epigenetic modifications that alter fetal cardiac programming and increase the risk of cardiovascular disease in adulthood.
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