Key result
Vitis vinifera L. grape skin extract (200 mg/kg/d) prevented the development of hypertension and restored normal lipid profiles in spontaneously hypertensive rats (p<0.05).
Why the study?
The study evaluated the effects of Vitis vinifera L. grape skin extract (ACH09) on blood pressure, lipid profile, and oxidative status in spontaneously hypertensive rats.
Does Vitis vinifera L. grape skin extract prevent the development of hypertension and altered lipid profiles in spontaneously hypertensive rats?
Does Vitis vinifera L. grape skin extract prevent the development of hypertension and altered lipid profiles in spontaneously hypertensive rats?
Chronic treatment with grape skin extract (ACH09) prevents the development of hypertension and dyslipidemia in spontaneously hypertensive rats, likely via antioxidant mechanisms.
L. grape skin extract (ACH09) on blood pressure, lipid profile, and oxidative status in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP), total cholesterol, triglyceride, and glucose levels, as well as oxidative damage and antioxidant activity in the plasma and kidney, were evaluated in four experimental groups: control Wistar rats (W-C) and SHR-C that received water, and Wistar rats and SHR treated with ACH09 (200 mg/kg/d) in drinking water for 12 weeks (W-ACH09 and SHR-ACH09, respectively). SBP increased in the SHR group compared with the W groups and the treatment with ACH09 prevented the development of hypertension. Plasma triglyceride and total cholesterol levels increased in SHR compared with W-C rats; these changes prevented by treatment with ACH09. Glucose levels did not differ between the groups. The SHR group had increased oxidative damage in plasma, as expressed by 2-thiobarbituric acid reactive substances (TBARS) levels, and this prevented by ACH09. Levels of TBARS in the kidneys were lower in the SHR-ACH09 group than in the SHR-C group. Further, ACH09 increased the superoxide dismutase activity in both the plasma and kidneys of both SHR and Wistar rats. These results suggest that ACH09 is protective against disruption of blood pressures, oxidant status, and lipid profile in SHR, and provide important evidence on the benefits of ACH09 on hypertension and associated cardiovascular complications.
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Costa et al. (2020) studied Hypertension (n=28). Vitis vinifera L. grape skin extract (ACH09) vs. Water was evaluated on Systolic blood pressure (SBP) (p=<0.05). Vitis vinifera L. grape skin extract (200 mg/kg/d) prevented the development of hypertension and restored normal lipid profiles in spontaneously hypertensive rats (p<0.05).
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