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Imipramine plasma level was determined after a single oral dose. Patients who responded to subsequent imipramine therapy showed low plasma levels, refractory cases showed high levels. The low plasma levels of responders continued during therapy. Their imipramine stool and urine excretions were also low. A differential binding of the drug according to psychopathology was discussed.
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Haydu et al. (1962) studied this question.
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