Key result
Domains D1 and D2 of the Na+ channel play a more prominent role in determining the slow inactivation phenotype than D3 and D4, based on patch clamp studies of human and rat chimaeras.
In human heart and rat skeletal muscle Na+ channel chimaeras, all four domains modulate the slow inactivation phenotype, with D1 and D2 playing a more prominent role.
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May guide domain-specific Na+ channel studies in arrhythmia models; leaves open human translation.
O’Reilly et al. (1999) studied this question. Na+ channel chimaeras (domains from hH1 and mu1) vs. Wild-type human heart (hH1) and rat skeletal muscle (mu1) Na+ channels was evaluated on Slow inactivation phenotype (development, steady state and recovery). Domains D1 and D2 of the Na+ channel play a more prominent role in determining the slow inactivation phenotype than D3 and D4, based on patch clamp studies of human and rat chimaeras.
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