Exposome-wide Association Study for Metabolic Syndrome

Figures

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  FIGURE 1. A conceptual framework of applying exposome-wide association study (EWAS) to investigate metabolic syndrome (MetS). The internal exposome includes but is not limited to all the non-endogenous agents inside the human body such as xenobiotics, their biotransformation products, and foreign biological agents. The Manhattan plot was used to illustrate how EWAS could potentially identify the most MetS-related factors in the exposome. Grey lines represent external-internal interactions; blue lines represent intra-internal interactions; and orange lines represent gene–exposome/microbiome interaction. Not all the relationships are presented.