Significance of Antibody to DNA in Systemic Lupus Erythematosus.

s1 April 1964Significance of Antibody to DNA in Systemic Lupus Erythematosus.George J. Friou, M.D., F.A.C.P., Salvador P. Casals, M.D., Lynn Myers, M.D., Perry O. Teague, M.D.George J. Friou, M.D., F.A.C.P.Search for more papers by this author, Salvador P. Casals, M.D.Search for more papers by this author, Lynn Myers, M.D.Search for more papers by this author, Perry O. Teague, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-741 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudy of antinuclear and other antitissue antibodies has contributed to the increasing interest in concepts of immunologic mechanisms of pathogenesis of mesenchymal diseases, especially systemic lupus erythematosus. In spite of this, there has been no clinical or direct experimental evidence relating any of the antinuclear antibodies to specific disease manifestations.It has been our contention that the significance of antinuclear antibodies can only be properly elucidated by studies which distinguish between individual factors. To facilitate distinction of antibodies with different specificities we have previously described a spot test for detection of antibody to nucleoprotein, and a characteristic nuclear reaction pattern... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George J. Friou, M.D., F.A.C.P.; Salvador P. Casals, M.D.; Lynn Myers, M.D.; Perry O. Teague, M.D.Affiliations: Oklahoma City, Oklahoma PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 741-741KeywordsAntinuclear antibodiesDNALupus erythematosusPathogenesisSpecificitySystemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...