2.3 Lf Disease—clinical Management

1) Investigate effects of MDA alone on progression or rever-sal of LF disease (lymphedema, filaricele, acute adenolym-phangitis [ADL]), 2) Evaluate comparative studies of filaricele surgical tech-niques for a) relapse rates, b) surgical costs and duration, c) post-operative complications, 3) Refine and standardize (through a consensus conference) clinical definitions of LF disease, and describe epidemiol-ogy of LF disease with these new definitions, 4) Improve differential diagnosis of pediatric LF disease, and initiate studies to define measures to prevent its progres-sion, 5) Investigate the value of traditional medicine approaches to lymphedema and urogenital disease, 6) Increase understanding of the skin barrier function, entry lesions, and ways of preventing the bacterial complications of LF disease, 7) Define epidemiology, risk factors, complications, and op-timal management of chyluria.