Amenorrhea from Breast Cancer Therapy — Not a Matter of Dose

To the Editor: In our article on concurrent versus sequential administration of chemotherapy drugs for women with operable, node-positive, early-stage breast cancer (June 3 issue),1 we report that premenopausal women in whom amenorrhea developed as a consequence of receiving adjuvant chemotherapy had a superior outcome to those without amenorrhea. In response to questions regarding our data analyses, we have performed two additional analyses. One is a 12-month landmark Kaplan–Meier analysis to address the concern that our previous results may have been biased by the misclassification of women without amenorrhea who had a relapse or died before reaching 24 months of . . .