The transformation of β‐chloroethyl esters (1) into acids (2) under extremely mild conditions, i.e. removal of the protecting group Cl(CH2)2, can be accomplished with zinc dust/NH4Cl or electrochemically. The catalyst is vitamin B12 or a model compound. Even lactam rings remain intact during the deprotection. equation image
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Scheffold et al. (1980) studied this question.
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