Bioactivity-directed isolation work on the New Zealand liverwort Hepatostolonophora paucistipula afforded the sesquiterpene lactones (-)- ent-costunolide (1) and (-)- ent-arbusculin B (2) as cytotoxic compounds. This is the first report of 1, enantiomeric to the known germacranolide (+)-costunolide (3).
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Baek et al. (2003) studied this question.
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