Key result
Patients with unstable angina had significantly higher serum DKK-1 levels (135.8 vs 36.6 ng/mL) and lower glutathione levels compared to healthy controls.
Why the study?
Inflammation is important in coronary artery disease, but the relationship between dickkopf-1, high mobility group box-1, and other biochemical markers in unstable angina required investigation.
Are serum DKK-1 and GSH levels altered in patients with unstable angina compared to healthy controls?
Case-Control (n=90)
No
Are serum DKK-1 and GSH levels altered in patients with unstable angina compared to healthy controls?
Absolute Event Rate: 135.8% vs 36.6%
p-value: p=<0.0001
Serum DKK-1 is elevated and GSH is reduced in patients with unstable angina, suggesting a potential role as inflammatory biomarkers.
Altered DKK-1 and GSH levels associate with unstable angina; leaves open their utility as biomarkers pending prospective validation.
Background: The importance of inflammation in coronary artery disease and the inflammatory biomarkers linked to adverse outcomes have recently been the subject of numerous investigations. In addition to examining the relationship between dickkopf-1 and high mobility group box-1 with other biochemical markers, this study seeks to ascertain the relationship between dickkopf-1 and high mobility group box-1 in patients whose angina pectoris is not stable. Methods: The work includes 50 patients (20 female and 30 male) and 40, 20 female and 20 males as controls who attended Al Ramadi Teaching Hospital between November 2021 and April. The sample age ranged between 52.16 ± 8.423 years in comparison to 49.58 ± 8.098 for the controls. Results: The serum DKK-1 levels (ng/mL) rose in unstable angina (UA) patients (135.527.13 for UA patients vs. 36.614.07 for the control group), so UA patients had higher DKK-1 release during platelet aggregation because DKK1 is involved in platelet-induced endothelial cell activation, so DKK1 causes inflammation. Additionally, the GSH was significantly lower in those having UA than in controls. Conclusion: Serum DKK-1 levels was significantly higher for those with UA compared to the healthy and there is a significant drop in GSH levels in people with UA than in controls.
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Musleh et al. (2023) conducted a case-control in Unstable angina (n=90). Unstable angina vs. Healthy controls was evaluated on Serum DKK-1 levels (ng/mL) (p=<0.0001). Patients with unstable angina had significantly higher serum DKK-1 levels (135.8 vs 36.6 ng/mL) and lower glutathione levels compared to healthy controls.
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