the genesis of pruritus ani.Faeces contain bacteria whose metabolic products include endopeptidases, which can produce itching in experimental conditions.5 6Although dysfunction of the anal sphincter itself may not be the cause of pruritus ani, it may be an important contributing factor.Further studies are required ofthe action of the sphincters in this condition, together with studies of the faecal and perianal skin flora.Nevertheless, the results reported here suggest an important new approach that may help to elucidate this trouble- some ailment.
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Goldwater et al. (1979) studied this question.
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