Outcomes of Pancreatic Resection for Elderly Patients With Pancreatic Cancer

This is the authors' abstract. We don't add key points for this paper.

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor, albeit gradually improving, prognosis. We evaluated the predictive clinicophysiologic outcomes of elderly patients with PDAC. Methods We retrospectively examined 260 patients who underwent pancreatic resection classified into 2 groups: (A) those who were ≤80 years of age (B) and those who were >80 years of age. Operative characteristics, preoperative clinicophysiologic parameters (body mass index, jaundice decompression, total bilirubin, albumin [Alb], creatinine, hemoglobin A1c, amylase, C-reactive protein [CRP], white blood cells, lymphocytes, hemoglobin, platelets, cancer antigen 19-9, carcinoembryonic antigen, neutrophil/lymphocyte ratio, prognostic nutritional index, platelet/lymphocyte ratio, and CRP/Alb ratio), disease-free survival (DFS), and overall survival (OS) were reported. Results There were no differences in morbidity, mortality, and preoperative clinicophysiologic parameters between the groups. Median DFS of groups A and B were 15.4 and 15.5 months, respectively. One-year/3-year OS of groups A and B were 86.7%/68% and 88.4%/69.3%, respectively. There were no differences in DFS and OS between the groups. Conclusion Curative resection for PDAC can be safely performed in elderly and younger patients, and elderly patients with PDAC can benefit from curative surgery without a significant decrease in survival rates.