Key result
Oral resveratrol supplementation mitigated impairments in neurovascular coupling following one night of restricted sleep (4 h time in bed) in young men and women.
Why the study?
Does oral resveratrol supplementation improve neurovascular coupling in young men and women following acute sleep restriction?
Does oral resveratrol supplementation improve neurovascular coupling in young men and women following acute sleep restriction?
Oral resveratrol supplementation may mitigate impairments in neurovascular coupling caused by acute sleep restriction.
Hypothesis-generating for resveratrol in acute sleep-related neurovascular impairment; larger trials required before clinical consideration.
Herein, we demonstrate that one night of restricted sleep (4 h time in bed) impairs the link between neural activity and cerebral blood flow (i.e., neurovascular coupling, NVC) of both middle and posterior cerebral arteries, and oral resveratrol supplementation may mitigate these impairments, particularly in the posterior cerebral artery. These results enhance our mechanistic understanding of sleep-associated impairments in NVC and advance our knowledge of neurovascular dysfunction occurring after restricted sleep.
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McDonald et al. (2025) studied Acute sleep restriction. Oral resveratrol supplementation was evaluated on Neurovascular coupling (NVC) of middle and posterior cerebral arteries. Oral resveratrol supplementation mitigated impairments in neurovascular coupling following one night of restricted sleep (4 h time in bed) in young men and women.
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