Case report reveals benign recovery following massive intravenous ofloxacin overdose in an adult, suggesting a substantial human safety margin.
A patient accidentally received approximately 3 g of ofloxacin intravenously. She experienced only moderately severe central nervous system symptoms, which resolved within 9 h. The peak serum ofloxacin level was 39.3 micrograms/ml, approximately seven times the usual peak level. Ofloxacin may possess a considerable safety margin in humans.
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Köhler et al. (1991) studied this question.
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