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C57BL cortisone‐resistant thymocytes were sensitized in vitro against DBA/2 alloantigens and tested for specific cytotoxicity against 51Cr‐labeled DBA/2 mastocytoma cells as targets. T cell sensitization, differentiation, uropod formation and specific cytotoxicity developed in a system of pure T lymphocytes and allogeneic antigenic fibroblasts without any apparent helper mechanism by other cell types or mediators.
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Lohmann‐Matthes et al. (1972) studied this question.
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