Integrating Au@MOF@COF nanocomposites for electrochemical aptasensing of trace oxytetracycline

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Developing efficient electrochemical aptasensors is one of the effective methods to address the thorny issue of antibiotic abuse that poses a threat to human health. Functional materials are crucial for improving detection performance. Combining the advantages of gold (Au) nanoparticles, metal-organic frameworks (MOFs), and covalent organic frameworks (COFs), a multivariate Au@MOF@COF nanocomposite is designed and synthesized to immobilize aptamers for electrochemical aptasensing of trace oxytetracycline (1.0 × 10–4 – 0.1 ng mL–1) with great sensitivity, good repeatability, fine stability, and remarkable selectivity. Especially, quantitative detection and analysis of oxytetracycline can be achieved in real milk samples using this aptasensor.