Key result
Increased preoperative right ventricular basal diameter was an independent predictor of long-term mortality (HR 1.06) after left ventricular surgical restoration, while right ventricular dysfunction alone did not significantly impact survival.
Why the study?
This study investigated the impact of preoperative right ventricular dysfunction and dilatation on survival outcomes following left ventricular surgical restoration in patients with ischemic cardiomyopathy.
Does preoperative right ventricular dysfunction and dilatation impact survival outcomes following left ventricular surgical restoration in patients with ischemic cardiomyopathy?
Cohort (n=137)
No
Does preoperative right ventricular dysfunction and dilatation impact survival outcomes following left ventricular surgical restoration in patients with ischemic cardiomyopathy?
Hazard Ratio: 1.06 (95% CI 1.02–1.09)
p-value: p=<0.01
Preoperative right ventricular basal diameter is an independent predictor of long-term mortality after left ventricular surgical restoration in patients with ischemic cardiomyopathy.
RV dysfunction may worsen post-LVSR survival; hypothesis-generating and requires prospective validation before influencing selection.
Background This study investigated the impact of preoperative right ventricular (RV) dysfunction and dilatation on survival outcomes following left ventricular surgical restoration (LVSR) in patients with ischemic cardiomyopathy. A retrospective analysis was conducted on 137 patients who underwent LVSR between 2009 and 2021. Results The results indicated that hospital mortality was significantly associated with older age [OR, 1.10; P = 0.01], higher EuroSCORE II [OR, 1.08, P = 0.03], recent myocardial infarction [OR, 4.24, P = 0.02], lower creatinine clearance [OR, 0.97, P = 0.02], and left ventricle longitudinal [OR, 0.95, P < 0.01] and transverse diameter [OR, 0.95; P < 0.01]. Although RV dysfunction alone did not significantly impact survival (log-rank P = 0.48), a trend toward lower survival rates was observed in patients with concurrent RV dilatation and dysfunction (log-rank P = 0.08). Long-term follow-up revealed no significant reduction in RV diameter after surgery. Multivariable analysis revealed that EuroSCORE II [HR, 1.05; P < 0.01], atrial fibrillation [HR, 3.34; P < 0.01], left ventricular longitudinal diameter [HR, 0.97; P < 0.01], and right ventricular basal diameter [HR, 1.06, P < 0.01] were independent predictors of long-term mortality. Conclusions This study underscores the importance of comprehensive preoperative evaluation of RV dimensions and function in predicting outcomes after LVSR, emphasizing the need for tailored management strategies for patients with RV abnormalities.
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Elsayed et al. (2025) conducted a cohort in Ischemic cardiomyopathy (n=137). Preoperative right ventricular dilatation (basal diameter) vs. Lower right ventricular basal diameter was evaluated on Long-term mortality (HR 1.06, 95% CI 1.02-1.09, p=<0.01). Increased preoperative right ventricular basal diameter was an independent predictor of long-term mortality (HR 1.06) after left ventricular surgical restoration, while right ventricular dysfunction alone did not significantly impact survival.
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