Metronidazole and Indian kala-azar: results of a clinical trial.

to progressive renal failure.Plasma phosphate and serum uric acid concentrations and blood pressure, however, were always within the normal range, and a renal biopsy specimen showed no evidence of interstitial nephritis and only minimal arteriolar hyalinisation.In the rat extensive renal ablation is followed by increases in glomerular capillary hydraulic pressure, glomerular capillary plasma flow rate, and single nephron glomerular filtration rate, and these changes may eventually cause glomerulosclerosis.3Similar processes may have occurred in this case.Children maintain stable renal function for up to 33 years after unilateral nephrectomy.4Our patient had lost a large proportion of his renal substance 19 years before he developed renal failure, suggesting that the eventual development of glomerulosclerosis in human remnant kidneys depends on both the number of remaining nephrons and the interval since injury.I Chanutin A, Ferris ED.Experimental renal insufficiency produced by partial nephrectomy.1.Control diet.