Original Articles: Prostate Cancer: Measurement of Serum Prostate Specific Antigen Levels in Women and in Prostatectomized Men With an Ultrasensitive Immunoassay Technique

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1995Original Articles: Prostate Cancer: Measurement of Serum Prostate Specific Antigen Levels in Women and in Prostatectomized Men With an Ultrasensitive Immunoassay Technique He Yu and Eleftherios P. Diamandis He YuHe Yu and Eleftherios P. DiamandisEleftherios P. Diamandis View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67622-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Serum prostate specific antigen (PSA) was measured in 89 prostate cancer patients with no evidence of relapse after radical prostatectomy, in 387 hospitalized women with various diseases and in 674 apparently healthy female blood donors, using an ultrasensitive time resolved immunofluorometric assay with a biological detection limit of 0.01 micrograms./l. Of the prostatectomized cancer patients 50% had measurable PSA (0.010 micrograms./l. or greater) and 21% had levels of 0.050 micrograms./l. or greater. Postoperative PSA was not associated with year of surgery, preoperative PSA or histological grade of the tumors. The distribution of PSA in 1,064 female sera is also reported, of which 83% had no detectable serum PSA, and in 15% PSA was between 0.010 and 0.049 micrograms./l. Only 27 subjects (2.5%) had PSA levels of 0.050 micrograms./l. or greater, including 16 (1.5%) with PSA of 0.10 micrograms./l. or greater. High serum PSA in women was associated with age 50 years or older. Further studies are needed to examine if the difference in PSA levels between women and prostatectomized men is due to residual or recurrent tumor or to other reasons associated with gender. References 1 : Cancer statistics, 1992. CA1992; 42: 19. Google Scholar 2 : Rise in prostatic cancer incidence associated with increased use of transurethral resection. J. 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Google Scholar From the Department of Clinical Biochemistry, Toronto Western Division, Toronto Hospital and Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario, Canada© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byTilki D, Kim S, Hu B, Dall'Era M and Evans C (2014) Ultrasensitive Prostate Specific Antigen and its Role after Radical Prostatectomy: A Systematic ReviewJournal of Urology, VOL. 193, NO. 5, (1525-1531), Online publication date: 1-May-2015.Kang J, Reiter R, Steinberg M and King C (2018) Ultrasensitive Prostate Specific Antigen after Prostatectomy Reliably Identifies Patients Requiring Postoperative RadiotherapyJournal of Urology, VOL. 193, NO. 5, (1532-1538), Online publication date: 1-May-2015.Doherty P, Friedman A, Migeon C, Macura K, Salmasi A and Lakshmanan Y (2012) Absence of Prostatic Growth in Large Cohort of Adult Female Patients with Congenital Adrenal HyperplasiaJournal of Urology, VOL. 188, NO. 4S, (1588-1595), Online publication date: 1-Oct-2012.GERSTENBLUTH R, SEFTEL A, HAMPEL N, OEFELEIN M and RESNICK M (2018) The Accuracy of the Increased Prostate Specific Antigen Level (Greater than or Equal to 20 Ng./Ml.) in Predicting Prostate Cancer: Is Biopsy Always Required?Journal of Urology, VOL. 168, NO. 5, (1990-1993), Online publication date: 1-Nov-2002.POLASCIK T, OESTERLING J and PARTIN A (2018) PROSTATE SPECIFIC ANTIGEN: A DECADE OF DISCOVERY-WHAT WE HAVE LEARNED AND WHERE WE ARE GOINGJournal of Urology, VOL. 162, NO. 2, (293-306), Online publication date: 1-Aug-1999.OBEK C, NEULANDER E, SADEK S and SOLOWAY M (2018) IS THERE A ROLE FOR DIGITAL RECTAL EXAMINATION IN THE FOLLOWUP OF PATIENTS AFTER RADICAL PROSTATECTOMY?Journal of Urology, VOL. 162, NO. 3 Part 1, (762-764), Online publication date: 1-Sep-1999.BIRKENMEIER G, STRUCK F and GEBHARDT R (2018) CLEARANCE MECHANISM OF PROSTATE SPECIFIC ANTIGEN AND ITS COMPLEXES WITH alpha 2-MACROGLOBULIN AND alpha 1-ANTICHYMOTRYPSINJournal of Urology, VOL. 162, NO. 3 Part 1, (897-901), Online publication date: 1-Sep-1999.Witherspoon L and Lapeyrolerie T (2018) Sensitive Prostate Specific Antigen Measurements Identify Men With Long Disease-Free Intervals and Differentiate Aggressive from Indolent Cancer Recurrences within 2 Years After Radical ProstatectomyJournal of Urology, VOL. 157, NO. 4, (1322-1328), Online publication date: 1-Apr-1997.Elgamal A, Ectors N, Sunardhi-Widyaputra S, Van Poppel H, Van Damme B and Baert L (2018) Detection of prostate specific antigen in pancreas and salivary glands: a potential impact on prostate cancer overestimationJournal of Urology, VOL. 156, NO. 2, (464-468), Online publication date: 1-Aug-1996. Volume 153Issue 3SMarch 1995Page: 1004-1008 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information He Yu More articles by this author Eleftherios P. Diamandis More articles by this author Expand All Advertisement PDF downloadLoading ...