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background Injectable hyaluronic acid was introduced to European markets in 1996 and has demonstrated a high safety profile. We describe the first reported case of angioedema-type hypersensitivity following injection of the upper lip with non–animal-stabilized hyaluronic acid (NASHA) gel. objective To report a case and discuss a potential mechanism for and treatment of angioedema-type hypersensitivity following injection with NASHA gel into the upper lip. methods and materials Not applicable. results Not applicable. conclusion Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed.
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Leonhardt et al. (2005) studied this question.
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