Key result
Exposure of healthy humans to three 2-hour hypoglycemic episodes over 30 hours significantly blunted epinephrine secretion (246 vs 496 pg/mL, P=0.02) and symptom responses to subsequent hypoglycemia on day 5.
Why the study?
Does exposure to three versus two episodes of moderate hypoglycemia blunt counterregulatory and symptom responses to subsequent hypoglycemia 5 days later in healthy humans?
Does exposure to three versus two episodes of moderate hypoglycemia blunt counterregulatory and symptom responses to subsequent hypoglycemia 5 days later in healthy humans?
Absolute Event Rate: 246% vs 496%
p-value: p=0.02
Exposure to three 2-hour hypoglycemic episodes over 30 hours creates a robust human model of hypoglycemia-associated autonomic failure lasting at least 5 days.
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May model prolonged HAAF in humans; leaves open translation to diabetes patients or practice change.
Moheet et al. (2013) studied Healthy humans (n=12). Three 2-hour periods of moderate hypoglycemia within 30 hours vs. Baseline (Day 1 response) was evaluated on Hypoglycemia-induced epinephrine secretion on day 5 compared to day 1 (p=0.02). Exposure of healthy humans to three 2-hour hypoglycemic episodes over 30 hours significantly blunted epinephrine secretion (246 vs 496 pg/mL, P=0.02) and symptom responses to subsequent hypoglycemia on day 5.
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