Key result
Omega-conotoxin GVIA (0.3-3 nmol) gradually attenuated atrial contractile force in a dose-dependent manner without affecting sinus rate in isolated canine right atria.
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Omega-conotoxin GVIA demonstrates a negative inotropic effect without affecting chronotropy in isolated canine atria.
Using an isolated, blood-perfused canine atrial preparation, we investigated the effects of omega-conotoxin GVIA (omega-CgTX), a blocker of N-type voltage-operated calcium channels, on the atrial contractile force and sinus rate. Omega-CgTX in a dose range of 0.3-3 nmol gradually attenuated the atrial contractile force in a dose-dependent manner, but did not affect the sinus rate, indicating that it can depress contractility but not pacemaker activity.
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Ren et al. (1991) studied this question. omega-conotoxin GVIA (omega-CgTX) was evaluated on atrial contractile force and sinus rate. Omega-conotoxin GVIA (0.3-3 nmol) gradually attenuated atrial contractile force in a dose-dependent manner without affecting sinus rate in isolated canine right atria.
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