Key result
Exposure to angiotensin II type 1 receptor antagonists during early pregnancy in 10 women resulted in abnormal fetal ultrasonography in 5 cases, 3 induced abortions, and 2 stillbirths.
Why the study?
Does exposure to angiotensin II type 1 receptor antagonists during early pregnancy cause fetal and neonatal toxicity?
Cohort (n=10)
No
Does exposure to angiotensin II type 1 receptor antagonists during early pregnancy cause fetal and neonatal toxicity?
Exposure to angiotensin II type 1 receptor antagonists during early pregnancy is associated with severe fetal toxicity, including renal abnormalities and fetal death, highlighting the need to stop treatment as soon as pregnancy is documented.
OBJECTIVE: Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin-angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy. DESIGN: Prospective follow up of pregnant women exposed to an ARA during early pregnancy. SETTING: The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debre in Paris, France. POPULATION: Ten women exposed to an ARA during early pregnancy. METHODS: Prospective follow up. MAIN OUTCOME MEASURE: Fetal ultrasonography and outcome of pregnancy. RESULTS: Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development. CONCLUSION: Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.
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Serreau et al. (2005) conducted a cohort in Pregnancy (n=10). Angiotensin II type 1 receptor antagonists (ARA) was evaluated on Fetal ultrasonography and outcome of pregnancy. Exposure to angiotensin II type 1 receptor antagonists during early pregnancy in 10 women resulted in abnormal fetal ultrasonography in 5 cases, 3 induced abortions, and 2 stillbirths.
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