Key result
Endothelial nitric oxide synthase localization and the molecular mechanisms regulating nitric oxide production are critical for understanding endothelial dysfunction in cardiovascular disease.
This paper highlights the importance of understanding the molecular mechanisms regulating endothelial nitric oxide production and its critical role in vascular homeostasis and cardiovascular disease pathogenesis.
ascular endothelium-derived nitric oxide (NO), originally identified as endothelium-derived relaxing factor, 1-3 plays a pivotal role in regulation of vascular homeostasis. NO is a major regulator of vascular tone and blood pressure, and has multiple antiatherogenic roles including antiinflammatory, antithrombotic, antiproliferative, and antioxidant effects. 4 -6 Loss of the bioavailability of endothelium-derived NO is the hallmark of endothelial dysfunction and is implicated in the pathogenesis of cardiovascular disease such as hypertension and atherosclerosis. Therefore, it is of great interest to understand the molecular mechanisms regulating NO production by endothelium, which is likely to provide new insight into endothelial function in health and disease.
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Zheng‐Gen Jin (2006) conducted an editorial in Cardiovascular disease. Endothelial nitric oxide synthase localization and the molecular mechanisms regulating nitric oxide production are critical for understanding endothelial dysfunction in cardiovascular disease.
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