All articles of this category A simple procedure for the synthesis of pyrrole-3,4-diacetic esters and N -derivatives thereof consists of the oxidative alkoxycarbonylation of dipropargylamine or N -derivatives to give 3,4-bis(alkoxycarbonylmethylene) pyrrolidines which can be easily isomerized to pyrrole-3,4-diacetic esters. Controlled hydrolysis of these esters affords pyrrolidine-3,4-diacetic acid.
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Chiusoli et al. (1989) studied this question.
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