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Following standardized mechanical vessel wall injury in rabbits, the duration of embolization was significantly longer in arterioles than venules (median 101 vs 17 s) with more emboli produced (6 vs 1).
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In a rabbit model, thromboembolic reactions following mechanical vessel wall injury differ significantly between arterioles and venules, with arterioles showing longer embolization duration and more emboli.
The walls of rabbit mesenteric arterioles and venules (diameter 20 to 40 microns) were punctured with glass micropipets (tip diameter 6 to 8 microns). Thromboembolic reactions resulting from this standardized, small mechanical vessel wall injury could be quantified in vivo with the use of intravital video-microscopy. Following induction of the injury thrombus growth started immediately (less than 0.1 s). Bleeding times were short, on the average less than 2 s, and did not differ between arterioles and venules. The duration of the embolization process was significantly longer in arterioles than in venules (median 101 and 17 s, respectively), and more emboli were produced in arterioles than in venules (median 6 and 1, respectively). Arteriolar thrombi were more effective in plugging the punctured holes than venular thrombi. The differences in thromboembolic reaction between arterioles and venules, as found in the present study, can probably not be explained by fluid dynamic factors.
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Egbrink et al. (1988) studied Thromboembolic reaction following vessel wall injury. Wall puncture in arterioles vs. Wall puncture in venules was evaluated on Duration of the embolization process (seconds). Following standardized mechanical vessel wall injury in rabbits, the duration of embolization was significantly longer in arterioles than venules (median 101 vs 17 s) with more emboli produced (6 vs 1).
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