Key result
The Isomune-LD rapid immunochemical method for LD1 activity demonstrated 100% sensitivity and 97% specificity for the diagnosis of myocardial infarction at 48 hours.
Why the study?
Does a rapid immunochemical assay for LD1 accurately diagnose myocardial infarction in patients evaluated for MI?
Observational (n=85)
Does a rapid immunochemical assay for LD1 accurately diagnose myocardial infarction in patients evaluated for MI?
The rapid immunochemical assay for LD1 demonstrates high sensitivity and specificity for diagnosing myocardial infarction within 48 hours of admission.
May support LD1 assay for MI diagnosis at 48 hours; leaves open prospective validation before practice change.
A rapid immunochemical method (Isomune-LD) for the determination of lactate dehydrogenase isoenzyme 1 (LD1) activity in serum was investigated, and the sensitivity and specificity of the assay were determined for the diagnosis of a myocardial infarction (MI). Multiple serum samples were obtained (on admission and at 12, 24, and 48 hours) from 85 patients (30 with proven MI and 55 without MI). The sensitivity of LD1 on admission and at 12, 24, and 48 hours was 43%, 84%, 96%, and 100%, respectively, and the specificity at these same time intervals was 95%, 100%, 97%, and 97%, respectively. Thus, the determination of LD1 by this rapid immunochemical method appears to allow a rapid laboratory evaluation of MI with a high degree of sensitivity and specificity.
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M. T. McCoy (1983) conducted an observational in Myocardial infarction (n=85). Isomune-LD rapid immunochemical method for LD1 vs. Patients without MI was evaluated on Sensitivity and specificity for the diagnosis of myocardial infarction. The Isomune-LD rapid immunochemical method for LD1 activity demonstrated 100% sensitivity and 97% specificity for the diagnosis of myocardial infarction at 48 hours.
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