Catenation of a circular oligonucleotide to a supercoiled plasmid can be achieved in high yields by means of ligand-induced triple-helix formation. The noncovalent interactions in this supramolecular structure can be modulated by a triplex-stabilizing agent (TSA; see picture). The circular oligonucleotide represents a noncovalent anchor for plasmid functionalization.
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Roulon et al. (2001) studied this question.
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