Key result
Vigorous hydration, loop diuresis, sodium bicarbonate, prostaglandin, and Shenkang injection successfully restored renal function, creatine kinase, and myoglobin to normal levels in a patient with exertional rhabdomyolysis-induced acute kidney injury.
Why the study?
Exertional rhabdomyolysis can cause life-threatening acute kidney injury, prompting an examination of its clinical presentation and key treatment process.
Case Report (n=1)
No
Vigorous hydration combined with sodium bicarbonate, furosemide, prostaglandin, and Shenkang injection successfully reversed severe acute kidney injury induced by exertional rhabdomyolysis in an elderly patient.
This is the authors' abstract. We don't add key points for this paper.
Background: The exRML (exertional rhabdomyolysis) is a pathophysiologic condition of skeletal muscle cell damage and breakdown associated with high intensity or prolonged exercise, normal exercise under extreme circumstances, or sudden and excessive skeletal muscle contraction. It may manifest from the increase in CK (creatine kinase) or MYO (myoglobin), a protein that can cause life-threatening injury to the kidney (AKI, acute kidney injury), and may or may not be associated with myoglobinuria. Here, we presented a case of exRML with AKI, and then reviewed the related reports. Vigorous hydration, sodium bicarbonate and furosemide are key treatments. Aim: To examine an elderly patient with exRML induced AKI and the key treatment process. Case summary: A 61-year-old man left our hospital without permission after his admission and has been walking for almost 30 kms with no water and food intake, then was diagnosed exRML and exRML induced AKI with an obvious elevation of CK, MYO and decrease of eGFR (estimated glomerular filtration rate) after coming back, and was treated with vigorous hydration, loop diuresis, sodium bicarbonate, prostaglandin and Shenkang injection. After vigorous resuscitation, the patient’s renal function, CK and MYO returned normal. Conclusions: The exRML can cause serious complications such as AKI and death. Delayed diagnosis can be critical; therefore, manner of time should be taken to achieve a favorable prognosis.
May aid recovery in exertional rhabdomyolysis AKI; hypothesis-generating and requires prospective validation before practice change.
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Yanwen Zhang (2024) conducted a case report in Exertional Rhabdomyolysis Induced Acute Kidney Injury (n=1). Vigorous hydration, loop diuresis, sodium bicarbonate, prostaglandin, and Shenkang injection was evaluated on Renal function, CK, and MYO recovery. Vigorous hydration, loop diuresis, sodium bicarbonate, prostaglandin, and Shenkang injection successfully restored renal function, creatine kinase, and myoglobin to normal levels in a patient with exertional rhabdomyolysis-induced acute kidney injury.
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