The synthesis of novel thiophene‐2‐carboxylic acids bearing alkyl and aryl‐substituted oxazole and oxadiazole rings is reported. Sequential functionalization of the key precursor, 5‐formyl‐2‐thiophenecarboxylic acid furnished the intermediate carboxylic acid esters which were converted into desired acids by basic cleavage.
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Carl J. Goddard (1991) studied this question.
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