A change for the better: The proximal cysteine thiolate in a cytochrome P450 enzyme is replaced by a selenocysteine. The resulting selenolate-ligated CYP119 protein has UV/Vis (see spectrum, ••••), EPR, and resonance Raman spectra that are similar to those of the native protein (—). These results are the first to fully describe a hemoprotein with a selenolate proximal ligand.
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Jiang et al. (2009) studied this question.
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