Make it quick! The oxygen isotope 15O has a half-life of only 2 min, and was incorporated into a sugar through an ultra-rapid radical hydroxylation of 2,6-dideoxy-6-iodo-D-glucose with labeled molecular oxygen to provide 6-[15O]-2-deoxy-D-glucose (see scheme). The product accumulates in metabolically active organs of rats similarly to a 18F-based tracer in common use, and represents a promising alternative for medical imaging.
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Yorimitsu et al. (2005) studied this question.
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