Key result
The rs7069102 GG genotype significantly mediated the relationship between age-related hemoglobin levels and fatigue across all SIRT1 plasma levels (β = -0.112, p = 0.007).
Why the study?
Fatigue is common among older people with chronic illnesses, but the interactive effects of hemoglobin, age, SIRT1, and rs7069102 were not well understood.
Cross-Sectional (n=129)
No
Effect estimate: β = -0.112 (95% CI -0.060 to -0.009)
p-value: p=0.007
In older adults with chronic illnesses, the SIRT1 rs7069102 GG genotype acts as a mediator that reduces the effect of age-related hemoglobin decline on fatigue.
Hypothesis-generating for SIRT1-mediated fatigue pathways; should not change practice without longitudinal confirmation.
Introduction: Fatigue is a common issue among the elderly with chronic illnesses.This pilot study examined the effects of hemoglobin, age, Sirtuin1 (SIRT1), and rs7069102 on fatigue in older persons with chronic illness in Indonesia.Methods: A cross-sectional study of 129 elderly individuals with chronic illnesses was conducted using a moderated mediation analysis.A questionnaire was used to evaluate fatigue, SIRT1 levels were measured using ELISA, and the genotypes of rs7069102 were identified using PCR-CTPP.Hayes' approach was used in both the mediation and moderated mediation studies.Results: Hemoglobin levels were negatively correlated with fatigue (r = -0.182,p = 0.038), but age was positively correlated with fatigue (r = 0.183, p = 0.039).The mediation analysis revealed that age had no significant effect on the relationship between hemoglobin level and fatigue.However, moderated mediation analysis indicated a significant indirect effect of the rs7069102 GG genotype on the relationship between hemoglobin, age, and fatigue at all SIRT1 levels (β(mean-1SD) = -0.100,p = 0.010; β(mean) = -0.112,p = 0.007; β(mean+1SD) = -0.122,p=0.006). Conclusion:This study shows that the rs7069102 GG genotype at all SIRT1 plasma levels acts as a mediator, reducing the effect of age-related hemoglobin on fatigue.These findings indicate the intricate interaction between genetic factors, physiological parameters, and fatigue perception in these individuals, suggesting further investigation. www.phypha.ir/ppjExperimental Research Article Physiology and Pharmacology 29 (2025) 240-250The global issue of chronic fatigue in the elderly is important.Chronic illness often causes severe fatigue (Goërtz et al., 2021).85% of the elderly population in developed regions have experienced at least one disease, with more than 60% having multiple chronic conditions
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Ardinata et al. (2025) conducted a cross-sectional in Chronic illness (n=129). Hemoglobin, age, SIRT1 levels, and rs7069102 genotype was evaluated on Fatigue (β = -0.112, 95% CI -0.060 to -0.009, p=0.007). The rs7069102 GG genotype significantly mediated the relationship between age-related hemoglobin levels and fatigue across all SIRT1 plasma levels (β = -0.112, p = 0.007).
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