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August 1, 1977Antimicrobial Agents and ChemotherapyOpen Access

Cytotoxicity and Cell Cycle Specificity of Homoharringtonine

David M. Baaske Peter Heinstein

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Abstract

The plant alkaloid, homoharringtonine, isolated from Cephalotaxus harringtonia is cytotoxic to HeLa, KB, and L cells growing in monolayer cell cultures. This effect appears to be cell-cycle specific. In synchronized KB cells, protein synthesis was preferentially inhibited in the G(1) and G(2) phases (70 and 45% inhibition, respectively) as might be expected for a protein-synthesis inhibitor.

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Baaske et al. (1977) studied this question.

synapsesocial.com/papers/6a9c2edf332d6b9421cc67b1 https://doi.org/10.1128/aac.12.2.298

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